Using Network Pharmacology to Explore the Mechanism of Huanglian Jiedu Decoction in the Treatment of Ulcerative Colitis

The aim of this study was to identify the potential compounds, core targets and possible mechanism Huanglian Jiedu decoction in treating ulcerative colitis based on network pharmacology molecular docking. At first, compounds were retrieved from traditional Chinese medicine systems pharmacology. And then, related obtained pharmacology, Online Mendelian Inheritance Man, GeneCards DisGeNET. Next, Cytoscape used visualize drug-compound-common target-disease protein-protein interaction network. Moreover, gene ontology Kyoto encyclopedia genes genomes enrichment analysis performed by database for annotation, visualization integrated discovery investigate against colitis. last, docking verified reliability prediction results. 55 84 screened out as players After analyses, 10 (quercetin, kaempferol, wogonin, baicalein, acacetin, 5-hydroxy-7-methoxy-2-(3,4,5- trimethoxyphenyl) chromone, beta-sitosterol, moslosooflavone, 5,7,4'-trihydroxy-8-methoxyflavone, oroxylin A) (interleukin-6, interleukin-1 beta, tumor necrosis factor-alpha, threonine-protein kinases, antigen p53, prostaglandin-endoperoxide synthase 2, JUN, CXCL8, C-C motif chemokine matrix metalloproteinase-9) identified. Furthermore, inflammatory response, factoralpha signaling pathway, pathways cancer, T cell receptor toll-like pathway nuclear factor kappa B may be involved treatment using decoction. This reveals that contains multiple ingredients, colitis, which provides a basis further research.